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10184 dPEG 8-SATA(S-acetyl-dPEG 8-NHS ester)

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CAS: 1070798-99-0

Item Name: dPEG 8-SATA(S-acetyl-dPEG 8-NHS ester)

Item #: 10184

Mol. Wt.: 597.67;

single compound dPEG Spacer is 28 atoms and 32.5 A

10184 dPEG 8-SATA(S-acetyl-dPEG 8-NHS ester)

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CAS: 1070798-99-0
Item Name: dPEG 8-SATA(S-acetyl-dPEG 8-NHS ester)
Item #: 10184
Mol. Wt.: 597.67;
single compound dPEG Spacer is 28 atoms and 32.5 A
Product Features and Benefits: Our dPEG pegylation version of the popular SATA reagent, providing a method for converting the amino group to a thiol with the incorporation of the pegylation unit Adds the amazing properties of dPEG , including added pegylation spacer distance, a spacer that is highly hydrophilic, non-antigenic, non-immunogenic and non-toxic Greater accessibility of reaction/modification site, i.e., spacer distance makes the amine, now thiol, much more accessible, e.g., a maleimide, vinyl sulfone or a ?-halo keto functionalize reaction partner. Protocols: Our experience suggests that using conditions similar to those used for SATA to remove the acetyl protecting group can be applied for the dPEG 4 SATA
Reference: Greg T. Hermanson, Bioconjugate Techniques, 2nd Ed, Elsevier Inc., Burlington, MA 01803, April, 2008 (ISBN-13: 978-0-12-370501-3; ISBN-10: 0-12-370501-0). References to SATA, which can be directly applied to the dPEG pegylation versions: a) general description and use, pg. 71; b) modification of antibodies, pg. 795; c) modification of amines on nucleotides and DNA probes, pg. 984 ; and c) modification of enzymes, avidin and streptavidin with, pg. 90,909, and 919.