| CAS #: 756525-96-9 Amount: 25mg  
Item Name: Biotin-dPEG®3-benzophenone Item #: 10267 Mol. Wt.: 654.82; single compound dPEG® Spacer is 15 atoms and 16.9 A Product Features and Benefits: Finally, an AFFORDABLE PHOTOREACTIVE biotinylation reagent for photoaffinity labeling with a pegylation spacer Contains a hydrophilic, non-immunogenic dPEG® pegylation spacer arm The additional advantages of benzophenone as a photoactivating group include the following: Does not react with an aqueous solvent medium when activated with light Activated with wavelengths least damaging to proteins (>300 nm) Stable in ambient light Gives non-specific insertion into C-H bonds in a variety of biologically relevant targets, especially HO-C-H Activation is non-photodissociative References: Excellent reviews for the general use of benzophenone containing compounds: G. Dorman and G. D. Prestwich, “Using Photolabile Ligands in Drug Discovery and Development,” Trends in Biotechnology, 18, 64-77 (2000). G. D. Prestwich, et al., “Benzophenone Photoprobes for Phosphoinositides, Peptides and Drugs,” Photochemistry and Photobiology, 65(2), 222-34 (1997). G. D. Prestwich, et. al., “Benzophenone Photophores in Biochemistry,” Biochemistry, 33(18), 5661-5673 (1993). |
