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COSMOSIL C18-OPN
Open column chromatography is an excellent and easy technique for large scale preparation
and purification at low cost. Reversed phase C18 packing materials are used but restricted to
about 30-50% water in the mobile phase. The COSMOSIL C18-OPN is a new "Water-Wet"
C18 packing material developed for Reversed Phase Open Column Chromatography.
The C18-OPN material can be used in 100% aqueous eluents
.
C18 packing materials in 100% water Normal C18 materials float on water
The external surface of the C18-OPN gel is coated with hydrophilic groups.
Effect of particle size
| Effect of particle size |
| Particle (m) |
Flow rate (ml/min) |
Theoretical plate number |
Rs |
Separation time(min) |
Consumption of solvent (ml) |
| TB |
TP |
CF |
Rs |
TB/TP |
TP/CF |
| 75 |
0.25 |
400 |
390 |
340 |
1.00 |
1.74 |
240 |
60 |
| 140 |
0.60 |
300 |
280 |
260 |
0.90 |
1.40 |
100 |
60 |
| 
