Thiol-dPEG®x-acid

Amount: 100mg

Item Name: Thiol-dPEG®12-acid

Item #: 10850

Mol. Wt.: 634.77;

single compound dPEG® Spacer is 39 atoms and 46.8 A approx.

Product Features and Benefits: Bifunctional thiol acids with dPEG® pegylation spacer Thiol is reactive with metal surfaces, other thiols, disulfides, maleimides, vinyl sulfones,and haloacetamides and incorporates the pegylation spacer into all of these various functionality Incorporates the dPEG® carboxylic acid dPEG® pegylation spacer is hydrophilic, highly water soluble, and non-immunogenic Once functionalized, the carboxylic acid moiety can be activated for further reaction, e.g. with EDC/NHS. Potentially activatable carboxylic acid moiety Product handling and stability: Keep product under an inert atmosphere to prevent oxidation to the disulfide; though the dPEG® thiol acids do not seem to be highly prone to oxidation Product is very soluble in methylene chloride and ethyl acetate, and is itself only slightly soluble in water as the acid. However, once reacted the hydrophilicity of the dPEG® pegylation spacer is imparted.

Reference: Greg T. Hermanson, Bioconjugate Techniques, 2nd Ed, Elsevier Inc., Burlington, MA 01803, April, 2008 (ISBN-13: 978-0-12-370501-3; ISBN-10: 0-12-370501-0).

Amount: 100mg

Item Name: Thiol-dPEG®20-acid

Item #: 10858

Mol. Wt.: 987.19;

single compound dPEG® Spacer is 63 atoms and 75.5 A approx.

Product Features and Benefits: Bifunctional thiol acids with dPEG® pegylation spacer Thiol is reactive with metal surfaces, other thiols, disulfides, maleimides, vinyl sulfones,and haloacetamides and incorporates the pegylation spacer into all of these various functionality Incorporates the dPEG® carboxylic acid dPEG® pegylation spacer is hydrophilic, highly water soluble, and non-immunogenic Once functionalized, the carboxylic acid moiety can be activated for further reaction, e.g. with EDC/NHS. Potentially activatable carboxylic acid moiety Product handling and stability: Keep product under an inert atmosphere to prevent oxidation to the disulfide; though the dPEG® thiol acids do not seem to be highly prone to oxidation Product is very soluble in methylene chloride and ethyl acetate, and is itself only slightly soluble in water as the acid. However, once reacted the hydrophilicity of the dPEG® pegylation spacer is imparted.

Reference: Greg T. Hermanson, Bioconjugate Techniques, 2nd Ed, Elsevier Inc., Burlington, MA 01803, April, 2008 (ISBN-13: 978-0-12-370501-3; ISBN-10: 0-12-370501-0).