Advanced Search   

Customer Service info@echemshop.com +1-302-292-8500

ST065835 GOSSYPOL

Quick Overview

GOSSYPOL

303-45-7

MFCD00017352

7-[8-formyl-1,6,7-trihydroxy-3-methyl-5-(methylethyl)(2-naphthyl)]-2,3,8-trihy droxy-6-methyl-4-(methylethyl)naphthalenecarbaldehyde

ST065835 GOSSYPOL

* Required Fields

$32.00

Details


IDENTIFIER
IDNUMBERNAMECASMDL
ST065835GOSSYPOL303-45-7MFCD00017352
IUPACNAME
7-[8-formyl-1,6,7-trihydroxy-3-methyl-5-(methylethyl)(2-naphthyl)]-2,3,8-trihy droxy-6-methyl-4-(methylethyl)naphthalenecarbaldehyde
Smiles
c1(c2c(c(c(c1O)O)C=O)c(c(c(c2)C)c1c(cc2c(c1O)c(c(c(c2C(C)C)O)O)C=O)C)O)C(C)C
TRADEMARK
INCHI
InChI=1S/C30H30O8/c1-11(2)19-15-7-13(5)21(27(35)23(15)17(9-31)25(33)29(19)37)22-14(6)8-16-20(12(3)4)30(38)26(34)18(10-32)24(16)28(22)36/h7-12,33-38H,1-6H3
INCHIKEY
InChIKey=QBKSWRVVCFFDOT-UHFFFAOYSA-N
Chem-Physical
FormulaMolecular WeightSALTAbsorption
C30H30O8518.560
LogPLogSLipinskyAcceptors
7.27-5.8218
DonorsRotation BondsChiral CentersN+O
61108
ACTIVITY
THERAPEUTIC CATEGORYVET THERAPEUTIC CATEGORY
Anticancer action
antitumor effects via an ROS (Reactive oxygen species)-dependent mitochondrial apoptosis in colorectal carcinoma non-specific calcineurin inhibitor Nonhormonal contraceptive for men Anticancer action
REFERENCE
Ko CH, et al. Gossypol reduction of tumor growth through ROS-dependent mitochondria pathway in human colorectal carcinoma cells. Int J Cancer. 2007 Jun 27 Carruthers NJ, et al. Gossypol inhibits calcineurin phosphatase activity at multiple sites. Eur J Pharmacol. 2007 Jan 26;555(2-3):106-14. Lopez LM, et al. Nonhormonal drugs for contraception in men: a systematic review. Obstet Gynecol Surv. 2005 Nov;60(11):746-52. Konac E, et al. An in vitro study of cytotoxic effects of gossypol on human epidermoid larynx carcinoma cell line (HEp-2). Exp Oncol. 2005 Mar;27(1):81-3