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ST023803 Solasodine

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Solasodine

126-17-0

MFCD09787895

(1S,2S,4S,7S,9S,12S,16S,8R,13R,26R)-7,9,13,23-tetramethyl-5-oxaspiro[pentacycl o[10.8.0.0<2,9>.0<4,8>.0<13,18>]icosane-6,6'-piperidine]-18-en-16-ol

ST023803 Solasodine

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$32.00

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IDENTIFIER
IDNUMBERNAMECASMDL
ST023803Solasodine126-17-0MFCD09787895
IUPACNAME
(1S,2S,4S,7S,9S,12S,16S,8R,13R,26R)-7,9,13,23-tetramethyl-5-oxaspiro[pentacycl o[10.8.0.0<2,9>.0<4,8>.0<13,18>]icosane-6,6'-piperidine]-18-en-16-ol
Smiles
C=12[C](CC[C@@H](C2)O)([C@@H]2([C@@H](CC1)([C@H]1([C](CC2)([C@@H]2([C@H](C1)(O[C]1([C@H]2C)NCC(CC1)C)))C))))C
TRADEMARK
INCHI
InChI=1S/C27H43NO2/c1-16-7-12-27(28-15-16)17(2)24-23(30-27)14-22-20-6-5-18-13-19(29)8-10-25(18,3)21(20)9-11-26(22,24)4/h5,16-17,19-24,28-29H,6-15H2,1-4H3/t16?,17-,19-,20+,21-,22-,23-,24-,25-,26-,27+/m0/s1
INCHIKEY
InChIKey=KWVISVAMQJWJSZ-DXZIWIJNSA-N
Chem-Physical
FormulaMolecular WeightSALTAbsorption
C27H43NO2413.641
LogPLogSLipinskyAcceptors
8.71-6.5632
DonorsRotation BondsChiral CentersN+O
20113
ACTIVITY
THERAPEUTIC CATEGORYVET THERAPEUTIC CATEGORY
Antiinflammatory activity Steroidal alkaloid solasodine is linked to impaired female sexual behavior of rat offspring Antiproliferative activities against human colon (HT29) and liver (HepG2) cancer cells
REFERENCE
Emmanuel S, et al. Antiinflammatory activity of Solanum trilobatum. Fitoterapia. 2006 Dec;77(7-8):611-2. Schwarz A, et al. Impaired female sexual behavior of rat offspring exposed to Solanum lycocarpum unripe fruits during gestation and lactation: lack of hormonal and fertility alterations. Pharmacol Biochem Behav. 2005 Aug;81(4):928-34 Bhatnagar P, et al. Production of solasodine by Solanum laciniatum using plant tissue culture technique. Indian J Exp Biol. 2004 Oct;42(10):1020-3 Lee KR, et al., Glycoalkaloids and metabolites inhibit the growth of human colon (HT29) and liver (HepG2) cancer cells. J Agric Food Chem. 2004 May 19;52(10):2832-9