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ST013856 Harman

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Harman

486-84-0

MFCD00004957

methylbeta-carboline

ST013856 Harman

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$32.00

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IDENTIFIER
IDNUMBERNAMECASMDL
ST013856Harman486-84-0MFCD00004957
IUPACNAME
methylbeta-carboline
Smiles
c1ccc2c([nH]c3c2ccnc3C)c1
TRADEMARK
INCHI
InChI=1S/C12H10N2/c1-8-12-10(6-7-13-8)9-4-2-3-5-11(9)14-12/h2-7,14H,1H3
INCHIKEY
InChIKey=PSFDQSOCUJVVGF-UHFFFAOYSA-N
Chem-Physical
FormulaMolecular WeightSALTAbsorption
C12H10N2182.221
LogPLogSLipinskyAcceptors
3.18-3.8440
DonorsRotation BondsChiral CentersN+O
1002
ACTIVITY
THERAPEUTIC CATEGORYVET THERAPEUTIC CATEGORY
Antibiotic
Antiplasmodial activity associated with a low cytotoxicity Monoamine oxidase (MAO) inhibitor inhibit HIV replication in H9 lymphocyte cells Antibiotic
REFERENCE
Merk 13, 4630 Fiot J, et al. Phytochemical and pharmacological study of roots and leaves of Guiera senegalensis J.F. Gmel (Combretaceae). J Ethnopharmacol. 2006 Jun 30;106(2):173-8. Epub 2006 Jan 27 Herraiz T, Chaparro C. Human monoamine oxidase enzyme inhibition by coffee and beta-carbolines norharman and harman isolated from coffee. Life Sci. 2006 Jan 18;78(8):795-802. Epub 2005 Aug 31 Ishida J,et al. Anti-AIDS agents. 46. Anti-HIV activity of harman, an anti-HIV principle from Symplocos setchuensis, and its derivatives. J Nat Prod. 2001 Jul;64(7):958-60 Aassila H, et al. Identification of harman as the antibiotic compound produced by a tunicate-associated bacterium. Mar Biotechnol (NY). 2003 Mar-Apr;5(2):163-6