Amino-dPEG®x-acids

Amount: 100mg

Item Name: Amino-dPEG®4-acid

Item #: 10244

Mol. Wt.: 265.30;

single compound dPEG® Spacer is 16 atoms and 18.0 A

Product Features and Benefits: Soluble and non-immunogenic Zwitterionic, extremely water soluble, and soluble in methylene chloride. Unprotected amino acid for those who prefer the potential simplicity of not having to remove one more protecting group. Pegylation reagent reacts selectively as the amine with NHS and other active esters in the presence of a 3o amine, e.g., TEA. The dPEG® amino acids can also be used in situ to make the methyl ester, which is generally not stable for extended periods of storage (see PN 10330 for kit and protocol). Spacer will minimize or eliminate aggregation problems with its incorporation into peptides and related compounds. Application: Surface and particle modification with terminal carboxyl functionality GREAT for coating beads in order to reduce non-specific binding problems React like common amino acids. The amine can be reacted selectively in the presence of an appropriate base with an activated ester Can be reacted in solvents as non-polar as methylene chloride

References: Greg T. Hermanson, Bioconjugate Techniques, 2nd Ed, Elsevier Inc., Burlington, MA 01803, April, 2008 (ISBN-13: 978-0-12-370501-3; ISBN-10: 0-12-370501-0). Chapter 14, pp. 582-626. Many of these can be applied to surfaces as well as particles, as Greg has emphasized in this chapter. A great picture of an optimal chemistry is shown in his Figure 14.5, pg. 591.. The example uses them in conjunction with the m-dPEG®x amines, generally equal to or shorter than the amino-dPEG® acid.

Amount: 100mg

Item Name: Amino-dPEG®12-acid

Item #: 10287

Mol. Wt.: 617.72;

single compound dPEG® Spacer is 40 atoms and 46.5 A

Product Features and Benefits: Soluble and non-immunogenic Zwitterionic, extremely water soluble, and soluble in methylene chloride. Unprotected amino acid for those who prefer the potential simplicity of not having to remove one more protecting group. Pegylation reagent reacts selectively as the amine with NHS and other active esters in the presence of a 3o amine, e.g., TEA. The dPEG® amino acids can also be used in situ to make the methyl ester, which is generally not stable for extended periods of storage (see PN 10330 for kit and protocol). Spacer will minimize or eliminate aggregation problems with its incorporation into peptides and related compounds. Application: Surface and particle modification with terminal carboxyl functionality GREAT for coating beads in order to reduce non-specific binding problems React like common amino acids. The amine can be reacted selectively in the presence of an appropriate base with an activated ester Can be reacted in solvents as non-polar as methylene chloride

References: Greg T. Hermanson, Bioconjugate Techniques, 2nd Ed, Elsevier Inc., Burlington, MA 01803, April, 2008 (ISBN-13: 978-0-12-370501-3; ISBN-10: 0-12-370501-0). Chapter 14, pp. 582-626. Many of these can be applied to surfaces as well as particles, as Greg has emphasized in this chapter. A great picture of an optimal chemistry is shown in his Figure 14.5, pg. 591.. The example uses them in conjunction with the m-dPEG®x amines, generally equal to or shorter than the amino-dPEG® acid.

Amount: 100mg

Item Name: Amino-dPEG®24-acid

Item #: 10317

Mol. Wt.: 1146.35;

single compound dPEG® Spacer is 76 atoms and 89 A

Product Features and Benefits: Soluble and non-immunogenic Zwitterionic, extremely water soluble, and soluble in methylene chloride. Unprotected amino acid for those who prefer the potential simplicity of not having to remove one more protecting group. Pegylation reagent reacts selectively as the amine with NHS and other active esters in the presence of a 3o amine, e.g., TEA. The dPEG® amino acids can also be used in situ to make the methyl ester, which is generally not stable for extended periods of storage (see PN 10330 for kit and protocol). Spacer will minimize or eliminate aggregation problems with its incorporation into peptides and related compounds. Application: Surface and particle modification with terminal carboxyl functionality GREAT for coating beads in order to reduce non-specific binding problems React like common amino acids. The amine can be reacted selectively in the presence of an appropriate base with an activated ester Can be reacted in solvents as non-polar as methylene chloride

References: Greg T. Hermanson, Bioconjugate Techniques, 2nd Ed, Elsevier Inc., Burlington, MA 01803, April, 2008 (ISBN-13: 978-0-12-370501-3; ISBN-10: 0-12-370501-0). Chapter 14, pp. 582-626. Many of these can be applied to surfaces as well as particles, as Greg has emphasized in this chapter. A great picture of an optimal chemistry is shown in his Figure 14.5, pg. 591.. The example uses them in conjunction with the m-dPEG®x amines, generally equal to or shorter than the amino-dPEG® acid.

Amount: 100mg

Item Name: Amino-dPEG®20-acid

Item #: 10927

Mol. Wt.: 970.14;

single compound dPEG® Spacer is 64 atoms and 75.2 A approx.

Product Features and Benefits: Soluble and non-immunogenic Zwitterionic, extremely water soluble, and soluble in methylene chloride. Unprotected amino acid for those who prefer the potential simplicity of not having to remove one more protecting group. Pegylation reagent reacts selectively as the amine with NHS and other active esters in the presence of a 3o amine, e.g., TEA. The dPEG® amino acids can also be used in situ to make the methyl ester, which is generally not stable for extended periods of storage (see PN 10330 for kit and protocol). Spacer will minimize or eliminate aggregation problems with its incorporation into peptides and related compounds. Application: Surface and particle modification with terminal carboxyl functionality GREAT for coating beads in order to reduce non-specific binding problems React like common amino acids. The amine can be reacted selectively in the presence of an appropriate base with an activated ester Can be reacted in solvents as non-polar as methylene chloride

References: Greg T. Hermanson, Bioconjugate Techniques, 2nd Ed, Elsevier Inc., Burlington, MA 01803, April, 2008 (ISBN-13: 978-0-12-370501-3; ISBN-10: 0-12-370501-0). Chapter 14, pp. 582-626. Many of these can be applied to surfaces as well as particles, as Greg has emphasized in this chapter. A great picture of an optimal chemistry is shown in his Figure 14.5, pg. 591.. The example uses them in conjunction with the m-dPEG®x amines, generally equal to or shorter than the amino-dPEG® acid.